Blood in the Urine (Hematuria)

Unexpected urine crystals and hematuria.

An otherwise healthy 6-year-old boy presented to the emergency department after falling out of bed and sustaining a testicular injury. The examination and evaluation, including urinalysis (revealing hematuria) and ultrasound, were suggestive of minor injury but were otherwise unremarkable. The patient was started on amoxicillin and had orders for a repeat urinalysis in a week. The microscopy re...

Standardization of Diagnostic Biomarker Concentrations in Urine: The Hematuria Caveat

Sensitive and specific urinary biomarkers can improve patient outcomes in many diseases through informing early diagnosis. Unfortunately, to date, the accuracy and translation of diagnostic urinary biomarkers into clinical practice has been disappointing. We believe this may be due to inappropriate standardization of diagnostic urinary biomarkers. Our objective was therefore to characterize the...

Routine urine cytology has no role in hematuria investigations.

PURPOSE Urine cytology has been a long-standing first line investigation for hematuria and is recommended in current major guidelines. We determined the contribution of urine cytology in hematuria investigations and its cost implications. MATERIALS AND METHODS Data were prospectively collected for 2,778 consecutive patients investigated for hematuria at a United Kingdom teaching hospital from...

Laboratory evaluation of discolored urine. When is it hematuria?

The Use of Molecular Analyses in Voided Urine for the Assessment of Patients with Hematuria

INTRODUCTION Patients presenting with painless hematuria form a large part of the urological patient population. In many cases, especially in younger patients, the cause of hematuria is harmless. Nonetheless, hematuria could be a symptom of malignant disease and hence most patients will be subject to cystoscopy. In this study, we aimed to develop a prediction model based on methylation markers ...